THE VITAMIN B12 AND FOLATE PATHOLOGY INVESTIGATION
THE INVESTIGATION OF ERRORS IN PATHOLOGY TESTS
FOR VITAMIN B12 AND FOLATE DEFICIENCY
BY MEANS OF MEDICAL EXPERIMENTS
THE SERUM VITAMIN B12 INVESTIGATION
THE SERUM B12 EXPERIMENT - A
Summary
Objectives
Findings
Method
Sample Collection
Analysis - CI
Analysis - Pxu
Analysis - Pab
Observations
Problems
Lab Performance
Results - Notes
Notes for Charts and Tables
Results - Assay Quality
Serum B12 Anomaly
Results - Analyte Utility
Serum B12 vs MMA
Serum B12 vs SNP HCY
Conclusions
Diagnositic Utility

Each week, I asked Sullivan Nicolaides Pathology to collect four tubes of my blood, and distribute them, as follows:

  • One tube for in-house analysis of serum B12
  • One tube for in-house analysis of total homocysteine (tHcy)
  • One tube for send out to QHPS
  • One tube for send out to Mater Pathology

A copy of the following diagram, illustrating the procedure, was provided with each request form following the loss of the samples for 17 July and 14 August.

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