THE HOMOCYSTEINE INVESTIGATION

THE VITAMIN B12 AND FOLATE PATHOLOGY INVESTIGATION

THE INVESTIGATION OF ERRORS IN PATHOLOGY TESTS

FOR VITAMIN B12 AND FOLATE DEFICIENCY

BY MEANS OF MEDICAL EXPERIMENTS

INTRODUCTION	THE SERUM VITAMIN B12 INVESTIGATION	THE METHYLMALONIC ACID INVESTIGATION
THE HOMOCYSTEINE INVESTIGATION	THE HOLOTRANSCOBALAMIN INVESTIGATION	THE FOLATE INVESTIGATION
REFERENCES AND LINKS	B12 AND FOLATE INFORMATION	RESPONSES TO INVESTIGATION

THE HCY EXPERIMENT

Summary

Method

Observations

Results - Notes

Results - Series 1

SNP Qualitative

Results - Series 1b

Conclusions

The important points to note, about response of homocysteine levels, from these SNP results are:

Initially 11.9, then 12.3 umol/L, well below maximum limit quoted by SNP.
Fell rapidly after commencing oral B12 on 2 November 2005, reaching minimum of 7.0 umol/L.
Increased again, remaining within the range 7.9 to 9.2 umol/L for several months.
Anomaly of 12.6 umol/L on 9 October 2006
Never exceeded the maximum limit quoted by SNP.
Fell rapidly after re-commencing oral B12 on 13 November 2006

Chart C19 Table C8