THE VITAMIN B12 AND FOLATE PATHOLOGY INVESTIGATION
THE INVESTIGATION OF ERRORS IN PATHOLOGY TESTS
FOR VITAMIN B12 AND FOLATE DEFICIENCY
BY MEANS OF MEDICAL EXPERIMENTS
THE SERUM VITAMIN B12 INVESTIGATION
SERUM B12 ERRORS
Summary
Laboratory Performance
Interpretation Errors
Erroneous Normal Levels
Immunoassays

Sullivan Nicolaides Pathology incorrectly quotes a "normal" level of >130 pmol/L for serum vitamin B12:

A level of 130 pmol/L is not considered normal by experts, reference DA01 to DA10, and a level below 295 pmol/L should be considered suspicious of B12 deficiency in the presence of symptoms. This is clear in the flowchart from Oh and Brown, reference DA01:

Oh and Brown

It is also clearly stated in the Abbott AxSym B12 Package Insert, reference AD01, supplied with the instrument used by Sullivan Nicolaides Pathology:

A serum B12 cut-of level of 200 pmol/L, for defining B12 deficiency, is recommended by Clarke et al, reference DA04.

Top of page

This web site is owned, designed and maintained by Paul Henry Golding of Nambour, QLD, Australia. © 2007-2016