THE VITAMIN B12 AND FOLATE PATHOLOGY INVESTIGATION
THE INVESTIGATION OF ERRORS IN PATHOLOGY TESTS
FOR VITAMIN B12 AND FOLATE DEFICIENCY
BY MEANS OF MEDICAL EXPERIMENTS
THE METHYLMALONIC ACID INVESTIGATION
THE MMA EXPERIMENT
Summary
Method
Observations
Results - Notes
Results - Series 1
MP vs WCH
Conclusions

The important points to note, about MMA levels, from these MP and WCH results are:

  • The two labs give totally different interpretations of my condition.
  • The WCH result shows a very distinct fall in MMA level from well above all of the cut-off levels, to well below the cut-offs after I commenced oral B12 treatment. This satisfies the criteria for diagnosis of vitamin B12 deficiency, as defined by many experts including Clarke et al, reference DA05.
  • Although the MP results show some fall in MMA level, following my oral B12 treatment, they fail to detect the fall below any of the cut-off levels.
  • This is caused by very significant imprecision in their analyses, leading to a serious difference in interpretation.
  • Mater Pathology repeated their analysis of the sample for 30 December 2005.
  • The newly reported MMA level was 0.21 umol/L, very significantly different to their original result of 0.8 umol/L for the same sample.
Chart C13 Table C8
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