THE VITAMIN B12 AND FOLATE PATHOLOGY INVESTIGATION
THE INVESTIGATION OF ERRORS IN PATHOLOGY TESTS
FOR VITAMIN B12 AND FOLATE DEFICIENCY
BY MEANS OF MEDICAL EXPERIMENTS
THE METHYLMALONIC ACID INVESTIGATION
THE MMA EXPERIMENT
Summary
Method
Observations
Results - Notes
Results - Series 1
Conclusions
Assay Quality

Only two out of the four labs to measure my MMA, WCH and Westmead, gave results that could be correctly interpreted as indicating the existence of cellular vitamin B12 deficiency.

Both Mater Pathology and QHPS repeatedly gave very significantly different results for identical samples, when each lab was asked to test two samples of the same date. The results from Mater pathology and QHPS also failed to show the actual increasing trend in MMA levels, making any correct interpretation of cellular vitamin B12 status impossible.

The significant analytical errors were, in my opinion, caused by failure in quality control, not by method differences; the methods used by all four labs have been proven by other labs.

Having regard to the results of my investigation, set out in this web site, in my opinion, neither Mater Pathology nor QHPS MMA results are of sufficient accuracy and precision to be relied on for the diagnosis or monitoring of vitamin B12 deficiency.

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