THE VITAMIN B12 AND FOLATE PATHOLOGY INVESTIGATION
THE INVESTIGATION OF ERRORS IN PATHOLOGY TESTS
FOR VITAMIN B12 AND FOLATE DEFICIENCY
BY MEANS OF MEDICAL EXPERIMENTS
THE METHYLMALONIC ACID INVESTIGATION
MMA ERRORS
Summary
Laboratory Performance
Interpretation Errors
Erroneous Normal Levels

Until 1 January 2006, Mater Pathology quoted a limit of 1.0 umol/L for MMA; since 1 January 2006, Mater Pathology has quoted a limit of 0.5 umol/L for MMA:

The first limit is far higher than what is quoted by any other lab that I am aware of. The second limit is shared only by Women's and Children's Hospital, Adelaide (WCH).

Most laboratories quote limits between 0.34 and 0.40 umol/L, the lowest being 0.28 umol/L; several are listed in reference AF03, AF10, AF11 and AF13. This table lists some of these limits, in umol/L:

Mayo
Cleveland
Sundhed
RPH
CHW
QHPS
0.40
0.376
0.28
0.35
0.34
0.40

Holleland et al, reference DA07, reported these findings:

 

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