THE VITAMIN B12 AND FOLATE PATHOLOGY INVESTIGATION
THE INVESTIGATION OF ERRORS IN PATHOLOGY TESTS
FOR VITAMIN B12 AND FOLATE DEFICIENCY
BY MEANS OF MEDICAL EXPERIMENTS
B12 AND FOLATE INFORMATION
B12 NOTES
Serum B12
Tests
MMA Testing Labs
Treatment
Sources of Information

These are the laboratories that I have located that are able to test for methylmalonic acid (see Links page for web sites):

Location
Laboratory
Australia

If you live in WA

Your sample for MMA will be sent to Princess Margaret Hospital, so you do not need to worry about where to send it. I am unable to comment on the quality of the assay performed at this lab, because they do not accept samples from interstate.

If you do not live in WA

I suggest that you specify that your samples be tested by the NSW Biochemical Genetics Service at The Children’s Hospital Westmead in Sydney. I suggest the following wording for the pathology request form:

“Serum Methylmalonic Acid and Total Homocysteine – NSW Biochemical Genetics Service, Children’s Hospital Westmead – please collect in one SST tube, spin, separate and send frozen”

If you do not specify this, and if you live in QLD, your samples will be sent to Mater Pathology or QHPS in Brisbane. I have explained in detail, in The MMA Investigation section, the reasons that I strongly recommend against using either of these Brisbane labs.

You could let your local lab do the homocysteine, but I suggest that you ask for Westmead to do it. Most labs use immunoassays for tHcy, which can be unreliable; Westmead uses Stable Isotope Dilution Tandem Mass Spectrometry, for both MMA and tHcy, which is the reference method used by Mayo Labs.

The MMA test will cost you $200 each, and there is no Medicare rebate; you might also have to pay the cost to have samples sent to Westmead. The total homocysteine will cost you $75 each; there should be some Medicare rebate for this test.

New Zealand

Canterbury Health Laboratories - serum MMA - requires doctor or lab referral

Europe

BioLab Medical Unit - 24-hour urine MMA test - requires doctor or lab referral

Scandinavia

Sundhed - see web site for individual labs

Canada

Hospitals In-Common Laboratory -random urine MMA - requires doctor or lab referral

USA

Norman Clinical Laboratory, Inc - offers random urine MMA test direct to patients

LabSafe - offers panel of tests direct to patients

Mayo Medical Laboratories - requires doctor or lab referral

UCDHSC Biochemical Genetics Laboratory - requires doctor or lab referral

The Reference Laboratory at the Cleveland Clinic - requires doctor or lab referral

LabCorp - requires doctor or lab referral

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