THE VITAMIN B12 AND FOLATE PATHOLOGY INVESTIGATION
THE INVESTIGATION OF ERRORS IN PATHOLOGY TESTS
FOR VITAMIN B12 AND FOLATE DEFICIENCY
BY MEANS OF MEDICAL EXPERIMENTS
B12 AND FOLATE INFORMATION
B12 NOTES
Serum B12
Tests
Introduction
Treatment
Sources of Information

Firstly, please be very careful about self-diagnosis. As stated on wrongdiagnosis.com (link G3 on the Links page):

Self diagnosis is a dangerous practice. In fact, it is one of the most likely ways to get a misdiagnosis, which is the one thing we want to avoid. We recommend you always seek prompt professional in-person medical advice from your local qualified medical professional.

I am aware that patients are sometimes left with no choice if their doctor is unable, or refuses, to help. If your current doctor is not helpful, try to find one who has an interest in nutritional medicine, and has an holistic approach.

Secondly, you need to be aware that there is no "gold standard" test for vitamin B12 deficiency. By this, I mean that there is no test that is always positive for a true case of deficiency, and always negative where there is no deficiency. This means that, for a single test, a negative result does not exclude deficiency. This is particularly true for total serum B12, where a high level does not exclude the existence of a true cellular deficiency.

This problem is clearly explained in Problems with the diagnosis of vitamin B12 deficiency, Perth Haematology, reference DB03 on the References page:

This difficulty with diagnosis is why it is especially important to try to work with a doctor who, in turn, should be able to work with the pathologists to interpret the results, to obtain the most accurate diagnosis possible. Unfortunately, there is no agreement on how to diagnose vitamin B12 deficiency.

Thirdly, I am not medically qualified and cannot give specific medical advice. The suggestions made on this page are based on my extensive Internet research, and on my own original research. The intended use of this information is for you to use it in cooperation with your doctor. If you choose, or are forced, to self-diagnose, then you must carefully consider any advice before acting on it.

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